Background:
@EN Increased isolation of methicillin-resistant Straphylococcus aureus has become one of the most important problem in treating staphylococcal infections. The aim of the study was to investigate the epidemiological characteristics of
antimicrobial
resistance of MRSA's isolated in the Kwangju area.
@ES Methods:
@EN 251 strains of S. aureus were isolated from various specimens from A-hospital and B-hospital and their resistance patterns against 19 antimicrobial agents and plasmid profiles studied. @ES Results:
@EN Methicillin resistance was detected in 74.2% and 46.1% of A-Hospital and B-hospital isolates, respectively. Resistance to cephalosporins and aminoglycosides was more frequent in the A-hospital isolates than in the B-hospital isolates, whereas
fosfomycin resistance was more frequent in the B-hospital isolates than in the A-hospital isolates. Frequency of resistance to ampicillin, tetracycline, chloramphenicol, ciprofloxacin in A-hospital isolates was similar to B-hospital isolates.
Strains
with multiple rosistance to more than 10 drugs were more frequent in the A-hospital isolates than that in the B-hospital isolates. Among MRSA strains, resistance to netilmicin and rifampin was more frequently encountered in A-hospital isolates,
while
resistance to fosfomycin, tetracyclin, and chloramphenicol was more frequent in B-hospital isolates. No differences in resistance patterns against other cephalosporins and aminoglycosides were observed between the two hospitals. Fosfomycin,
netilmicin,
chloramphenicol and rifampin resistances were different between the two hospitals in strains with multiple resistance. The most frequently observed multiple resistance patterns observed among A hospital isolates were
AmcCtxCzolLmoxGmTobLcmAmkNetTcEmRfp
and AmcCtxCzolCmdlLmoxFomGmTobLcmAmkNetTcEmRfp. Among B-hospital isolates, AmcCtxCzolLmoxFomGmTobLcmAmkChpTcEm pattern was the most frequent.
@ES Conclusion:
@EN MRSA strains from both hospitals showed cross-resistance toβ-lactams and aminoglycosides. Plasmid profiles from MRSA strains were different, according to the multiple resistance patterns. Characteristically, 108 kb plasmid was detected only
in
A-hospital-MRSA strains, while 2.8 kb plasmid was detected only in B-hospital-MRSA strains.
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